Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration

BACKGROUND: Metabolic reprogramming is shaped to support specific cell functions since cellular metabolism controls the final outcome of immune response. Multiple sclerosis (MS) is an autoimmune disease resulting from loss of immune tolerance against central nervous system (CNS) myelin. Metabolic al...

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Publicado no:Metabolism
Main Authors: La Rocca, Claudia, Carbone, Fortunata, De Rosa, Veronica, Colamatteo, Alessandra, Galgani, Mario, Perna, Francesco, Lanzillo, Roberta, Brescia Morra, Vincenzo, Orefice, Giuseppe, Cerillo, Ilaria, Florio, Ciro, Maniscalco, Giorgia Teresa, Salvetti, Marco, Centonze, Diego, Uccelli, Antonio, Longobardi, Salvatore, Visconti, Andrea, Matarese, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: W.B. Saunders 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800394/
https://ncbi.nlm.nih.gov/pubmed/29132538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2017.08.011
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