Manufacturing history of etanercept (Enbrel(®)): Consistency of product quality through major process revisions

Etanercept (ETN) (Enbrel®) is a soluble protein that binds to, and specifically inhibits, tumor necrosis factor (TNF), a proinflammatory cytokine. ETN is synthesized in Chinese hamster ovary cells by recombinant DNA technology as a fusion protein, with a fully human TNFRII ectodomain linked to the F...

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Pubblicato in:MAbs
Autori principali: Hassett, Brian, Singh, Ena, Mahgoub, Ehab, O'Brien, Julie, Vicik, Steven M., Fitzpatrick, Brian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800370/
https://ncbi.nlm.nih.gov/pubmed/29020515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1388483
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