Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms

While α(sk)-actin isoforms predominate in adult striated muscle, skeletal muscle-specific knockouts of non-muscle cytoplasmic β(cyto)- or γ(cyto)-actin each cause a mild, but progressive myopathy affected by an unknown mechanism. Using transmission electron microscopy, we identified morphological ab...

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Bibliografiska uppgifter
I publikationen:FEBS J
Huvudupphovsmän: O’Rourke, Allison R., Lindsay, Angus, Tarpey, Michael D., Yuen, Samantha, McCourt, Preston, Nelson, D’anna M., Perrin, Benjamin J., Thomas, David D., Spangenburg, Espen E., Lowe, Dawn A., Ervasti, James M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799018/
https://ncbi.nlm.nih.gov/pubmed/29265728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14367
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