Mechanism of transcription anti-termination in human mitochondria

In human mitochondria, transcription termination events at a G-quadruplex region near the replication origin are thought to drive replication of mtDNA by generation of an RNA primer. This process is suppressed by a key regulator of mtDNA – the transcription factor TEFM. We determined the structure o...

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Pubblicato in:Cell
Autori principali: Hillen, Hauke S., Parshin, Andrey V., Agaronyan, Karen, Morozov, Yaroslav I., Graber, James J., Chernev, Aleksandar, Schwinghammer, Kathrin, Urlaub, Henning, Anikin, Michael, Cramer, Patrick, Temiakov, Dmitry
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798601/
https://ncbi.nlm.nih.gov/pubmed/29033127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.035
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