A novel intermediate in transcription initiation by human mitochondrial RNA polymerase

The mitochondrial genome is transcribed by a single-subunit T7 phage-like RNA polymerase (mtRNAP), structurally unrelated to cellular RNAPs. In higher eukaryotes, mtRNAP requires two transcription factors for efficient initiation—TFAM, a major nucleoid protein, and TFB2M, a transient component of mt...

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Bibliografiska uppgifter
Huvudupphovsmän: Morozov, Yaroslav I., Agaronyan, Karen, Cheung, Alan C. M., Anikin, Michael, Cramer, Patrick, Temiakov, Dmitry
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
Ämnen:
Nucleic Acid Enzymes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973326/
https://ncbi.nlm.nih.gov/pubmed/24393772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1356
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