The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation

Microglia cells fulfill key homeostatic functions and essentially contribute to host defense within the CNS. Altered activation of microglia, in turn, has been implicated in neuroinflammatory and neurodegenerative diseases. In this study, we identify the nuclear receptor (NR) Nr4a1 as key rheostat c...

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Bibliografiska uppgifter
I publikationen:J Immunol
Huvudupphovsmän: Rothe, Tobias, Ipseiz, Natacha, Faas, Maria, Lang, Stefanie, Perez-Branguli, Francesc, Metzger, Daniel, Ichinose, Hiroshi, Winner, Beate, Schett, Georg, Krönke, Gerhard
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798579/
https://ncbi.nlm.nih.gov/pubmed/28411187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600638
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