12/15-lipoxygenase–mediated enzymatic lipid oxidation regulates DC maturation and function

DCs are able to undergo rapid maturation, which subsequently allows them to initiate and orchestrate T cell–driven immune responses. DC maturation must be tightly controlled in order to avoid random T cell activation and development of autoimmunity. Here, we determined that 12/15-lipoxygenase–medita...

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Pubblicato in:J Clin Invest
Autori principali: Rothe, Tobias, Gruber, Florian, Uderhardt, Stefan, Ipseiz, Natacha, Rössner, Susanne, Oskolkova, Olga, Blüml, Stephan, Leitinger, Norbert, Bicker, Wolfgang, Bochkov, Valery N., Yamamoto, Masayuki, Steinkasserer, Alexander, Schett, Georg, Zinser, Elisabeth, Krönke, Gerhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463199/
https://ncbi.nlm.nih.gov/pubmed/25844901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78490
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