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Off-Target Anti-Inflammatory Activity of the P2X7 Receptor Antagonist AZ11645373
We have found that a well-characterized P2X7 receptor antagonist AZ11645373 blocked production of pro-inflammatory chemokine IL-8 in endothelial cells treated with OxPAPC. The effect was not due to toxicity of AZ11645373 as documented by cellular metabolic activity assay. The mechanism of inhibition...
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| Publicado en: | Inflammation |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer US
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5357502/ https://ncbi.nlm.nih.gov/pubmed/28101847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10753-016-0499-8 |
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