Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease

BACKGROUND: Safe and effective delivery of therapeutic drugs to the brain is important for successful therapy of Alzheimer’s disease (AD). PURPOSE: To develop Huperzine A (HupA)-loaded, mucoadhesive and targeted polylactide-co-glycoside (PLGA) nanoparticles (NPs) with surface modification by lactofe...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Nanomedicine
Hauptverfasser: Meng, Qingqing, Wang, Aiping, Hua, Hongchen, Jiang, Ying, Wang, Yiyun, Mu, Hongjie, Wu, Zimei, Sun, Kaoxiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2018
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798568/
https://ncbi.nlm.nih.gov/pubmed/29440896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S151474
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