Toward Personalised Liquid Biopsies for Urothelial Carcinoma: Characterisation of ddPCR and Urinary cfDNA for the Detection of the TERT 228 G>A/T Mutation

BACKGROUND: TERT promotor mutations are present in >75% of bladder tumours; these mutations are also detectable in urine. Previous studies have used urinary pellet DNA, and semi-quantitative methods unsuitable for detecting very low mutant allele frequencies. OBJECTIVE: In this proof-of-principle...

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Vydáno v:Bladder Cancer
Hlavní autoři: Russo, Ilaria J., Ju, Yongwon, Gordon, Naheema S., Zeegers, Maurice P., Cheng, K.K., James, Nicholas D., Bryan, Richard T., Ward, Douglas G.
Médium: Artigo
Jazyk:Inglês
Vydáno: IOS Press 2018
Témata:
Research Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798520/
https://ncbi.nlm.nih.gov/pubmed/29430506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/BLC-170152
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