Toward Personalised Liquid Biopsies for Urothelial Carcinoma: Characterisation of ddPCR and Urinary cfDNA for the Detection of the TERT 228 G>A/T Mutation

BACKGROUND: TERT promotor mutations are present in >75% of bladder tumours; these mutations are also detectable in urine. Previous studies have used urinary pellet DNA, and semi-quantitative methods unsuitable for detecting very low mutant allele frequencies. OBJECTIVE: In this proof-of-principle...

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Detalles Bibliográficos
Publicado en:Bladder Cancer
Main Authors: Russo, Ilaria J., Ju, Yongwon, Gordon, Naheema S., Zeegers, Maurice P., Cheng, K.K., James, Nicholas D., Bryan, Richard T., Ward, Douglas G.
Formato: Artigo
Idioma:Inglês
Publicado: IOS Press 2018
Assuntos:
Research Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798520/
https://ncbi.nlm.nih.gov/pubmed/29430506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/BLC-170152
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