Loss of an Androgen-Inactivating and Isoform-Specific HSD17B4 Splice Form Enables Emergence of Castration-Resistant Prostate Cancer

Castration-resistant prostate cancer (CRPC) requires tumors to engage metabolic mechanisms that allow sustained testosterone and/or dihydrotestosterone to stimulate progression. 17β-Hydroxyste-roid dehydrogenase type 4 (17βHSD4), encoded by HSD17B4, is thought to inactivate testosterone and dihydrot...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Ko, Hyun-Kyung, Berk, Michael, Chung, Yoon-Mi, Willard, Belinda, Bareja, Rohan, Rubin, Mark, Sboner, Andrea, Sharifi, Nima
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798464/
https://ncbi.nlm.nih.gov/pubmed/29346776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.12.081
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