Molecular characterization of latent GDF8 reveals mechanisms of activation

Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. Using a combination of small-angle X-ray scattering and mutagenesis, we characterized the interactions of GDF8 w...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Walker, Ryan G., McCoy, Jason C., Czepnik, Magdalena, Mills, Melanie J., Hagg, Adam, Walton, Kelly L., Cotton, Thomas R., Hyvönen, Marko, Lee, Richard T., Gregorevic, Paul, Harrison, Craig A., Thompson, Thomas B.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798348/
https://ncbi.nlm.nih.gov/pubmed/29348202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714622115
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