Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer

d-2-hydroxyglutarate (D2HG) is produced in the tricarboxylic acid cycle and is quickly converted to α-ketoglutarate by d-2-hydroxyglutarate dehydrogenase (D2HGDH). In a mouse model of colitis-associated colon cancer (CAC), urine level of D2HG during colitis correlates positively with subsequent poly...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Han, Jie, Jackson, Dakota, Holm, Janette, Turner, Kevin, Ashcraft, Paula, Wang, Xuan, Cook, Beth, Arning, Erland, Genta, Robert M., Venuprasad, K., Souza, Rhonda F., Sweetman, Lawrence, Theiss, Arianne L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798335/
https://ncbi.nlm.nih.gov/pubmed/29339485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712625115
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