Tumor suppressor APC is an attenuator of spindle-pulling forces during C. elegans asymmetric cell division

The adenomatous polyposis coli (APC) tumor suppressor has dual functions in Wnt/β-catenin signaling and accurate chromosome segregation and is frequently mutated in colorectal cancers. Although APC contributes to proper cell division, the underlying mechanisms remain poorly understood. Here we show...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Sugioka, Kenji, Fielmich, Lars-Eric, Mizumoto, Kota, Bowerman, Bruce, van den Heuvel, Sander, Kimura, Akatsuki, Sawa, Hitoshi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798331/
https://ncbi.nlm.nih.gov/pubmed/29348204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712052115
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