Tumor suppressor APC is an attenuator of spindle-pulling forces during C. elegans asymmetric cell division

The adenomatous polyposis coli (APC) tumor suppressor has dual functions in Wnt/β-catenin signaling and accurate chromosome segregation and is frequently mutated in colorectal cancers. Although APC contributes to proper cell division, the underlying mechanisms remain poorly understood. Here we show...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Sugioka, Kenji, Fielmich, Lars-Eric, Mizumoto, Kota, Bowerman, Bruce, van den Heuvel, Sander, Kimura, Akatsuki, Sawa, Hitoshi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2018
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798331/
https://ncbi.nlm.nih.gov/pubmed/29348204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712052115
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