Caveolin-1 promotes the tumor suppressor properties of oncogene-induced cellular senescence

Oncogene-induced senescence (OIS) is considered a powerful tumor suppressor mechanism. Caveolin-1 acts as a scaffolding protein to functionally regulate signaling molecules. We demonstrate that a lack of caveolin-1 expression inhibits oncogenic K-Ras (K-Ras(G12V))-induced premature senescence in mou...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Volonte, Daniela, Vyas, Avani R., Chen, Chen, Dacic, Sanja, Stabile, Laura P., Kurland, Brenda F., Abberbock, Shira R., Burns, Timothy F., Herman, James G., Di, Yuanpu Peter, Galbiati, Ferruccio
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2018
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798308/
https://ncbi.nlm.nih.gov/pubmed/29247004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815902
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