CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression

Both long-term potentiation (LTP) and depression (LTD) of excitatory synapse strength require the Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) and its autonomous activity generated by Thr-286 autophosphorylation. Additionally, LTP and LTD are correlated with dendritic spine enlargeme...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Woolfrey, Kevin M., O'Leary, Heather, Goodell, Dayton J., Robertson, Holly R., Horne, Eric A., Coultrap, Steven J., Dell'Acqua, Mark L., Bayer, K. Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798287/
https://ncbi.nlm.nih.gov/pubmed/29196604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813808
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