A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models

The protein-tyrosine phosphatase PTP1B is a negative regulator of insulin and leptin signaling and a highly validated therapeutic target for diabetes and obesity. Conventional approaches to drug development have produced potent and specific PTP1B inhibitors, but these inhibitors lack oral bioavailab...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Krishnan, Navasona, Konidaris, Konstantis F., Gasser, Gilles, Tonks, Nicholas K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Accelerated Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798283/
https://ncbi.nlm.nih.gov/pubmed/29217773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C117.819110
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