Nalaganje...
A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models
The protein-tyrosine phosphatase PTP1B is a negative regulator of insulin and leptin signaling and a highly validated therapeutic target for diabetes and obesity. Conventional approaches to drug development have produced potent and specific PTP1B inhibitors, but these inhibitors lack oral bioavailab...
Shranjeno v:
| izdano v: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2018
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5798283/ https://ncbi.nlm.nih.gov/pubmed/29217773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C117.819110 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|