Celastrol Alleviates Airway Hyperresponsiveness and Inhibits Th17 Responses in Obese Asthmatic Mice

Severe airway hyperresponsiveness (AHR) is a clinical feature of asthma, which has been associated with obesity and has shown a poor response to standard asthma treatments such as glucocorticoids. Numerous studies have shown that Interleukin (IL)-17 producing CD4(+)T cells (Th17 cells), which could...

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Publicado en:Front Pharmacol
Autores principales: Zeng, Zeyu, Lin, Xixi, Zheng, Rongying, Zhang, Hui, Zhang, Weixi
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797758/
https://ncbi.nlm.nih.gov/pubmed/29445341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00049
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