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Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers

p53 mutations are frequently detected in malignant gastric cancers. However, the molecular mechanisms by which loss of p53 function promotes gastric cancer are not clear. We utilized Gan mice (K19-Wnt1/C2mE), which have functional p53 and develop intestinal-type gastric tumors, to investigate the ro...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Ohtsuka, Junko, Oshima, Hiroko, Ezawa, Issei, Abe, Ryo, Oshima, Masanobu, Ohki, Rieko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797237/
https://ncbi.nlm.nih.gov/pubmed/29396430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20572-1
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