Ormeloxifene-induced unfolded protein response contributes to autophagy-associated apoptosis via disruption of Akt/mTOR and activation of JNK

Autophagy, a regulated nutrient recycling program can affect both cell survival and cell death. Here, we show that Ormeloxifene (ORM), a selective estrogen receptor modulator approved for oral contraceptive use induces autophagic flux in ovarian cancer cells, which is activated by an ER stress respo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bhattacharjee, Arindam, Hasanain, Mohammad, Kathuria, Manoj, Singh, Akhilesh, Datta, Dipak, Sarkar, Jayanta, Mitra, Kalyan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797234/
https://ncbi.nlm.nih.gov/pubmed/29396506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20541-8
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