Sensitive detection of mitochondrial DNA variants for analysis of mitochondrial DNA-enriched extracts from frozen tumor tissue

Large variation exists in mitochondrial DNA (mtDNA) not only between but also within individuals. Also in human cancer, tumor-specific mtDNA variation exists. In this work, we describe the comparison of four methods to extract mtDNA as pure as possible from frozen tumor tissue. Also, three state-of-...

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Publicat a:Sci Rep
Autors principals: Weerts, M. J. A., Timmermans, E. C., Vossen, R. H. A. M., van Strijp, D., Van den Hout–van Vroonhoven, M. C. G. N., van IJcken, W. F. J., van der Zaag, P. J., Anvar, S. Y., Sleijfer, S., Martens, J. W. M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797170/
https://ncbi.nlm.nih.gov/pubmed/29396409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20623-7
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