APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response

APOBEC enzymes are responsible for a mutation signature (TCW>T/G) implicated in a wide variety of tumors. We explore the APOBEC mutational signature in bladder cancer and the relationship with specific mutations, molecular subtype, gene expression, and survival using sequencing data from The Canc...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Glaser, Alexander P., Fantini, Damiano, Wang, Yiduo, Yu, Yanni, Rimar, Kalen J., Podojil, Joseph R., Miller, Stephen D., Meeks, Joshua J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796993/
https://ncbi.nlm.nih.gov/pubmed/29435122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23344
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