High-Mobility Group Box 1 Mediates Fibroblast Activity via RAGE-MAPK and NF-κB Signaling in Keloid Scar Formation

Emerging studies have revealed the involvement of high-mobility group box 1 (HMGB1) in systemic fibrotic diseases, yet its role in the cutaneous scarring process has not yet been investigated. We hypothesized that HMGB1 may promote fibroblast activity to cause abnormal cutaneous scarring. In vitro w...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Kim, Jihee, Park, Jong-Chul, Lee, Mi Hee, Yang, Chae Eun, Lee, Ju Hee, Lee, Won Jai
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796026/
https://ncbi.nlm.nih.gov/pubmed/29283384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19010076
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