Intramuscular primary immunization by nucleic acid vaccine pcDNA/Gpd-IL-2 and enhanced immunization with mucosal adjuvant CpG-ODN and Gpd-IL-2 recombinant protein effectively induced strong mucosal immune responses and immune protective effects against Treponema pallidum skin infection

The present study aimed to evaluate the immune effect of intramuscular primary immunization by the nucleic acid vaccine pcDNA/glycerophosphodiester phosphodiesterase-interleukin-2 (pcDNA/Gpd-IL-2) and enhanced immunization 2 weeks later with the combination of mucosal adjuvant CpG-oligodeoxynucleoti...

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Detalhes bibliográficos
Publicado no:Exp Ther Med
Main Authors: Zhang, Xiaohong, Zhao, Tie, Zeng, Tiebing, Wu, Ning, Xiao, Yongjian, Liu, Shuangquan, Yu, Jian, Jiang, Chuanhao, Gan, Lin, Deng, Meixia, Luo, Xi, Zhao, Feijun
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795528/
https://ncbi.nlm.nih.gov/pubmed/29456657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2018.5689
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