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Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression

One of the causal genes for holoprosencephaly (HPE) is ZIC2 (HPE5). It belongs to the zinc finger protein of the cerebellum (Zic) family of genes that share a C2H2-type zinc finger domain, similar to the GLI family of genes. In order to clarify the role of Zic2 in gene regulation, we searched for it...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Ishiguro, Akira, Hatayama, Minoru, Otsuka, Maky I., Aruga, Jun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794963/
https://ncbi.nlm.nih.gov/pubmed/29391420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20242-2
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