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Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression

One of the causal genes for holoprosencephaly (HPE) is ZIC2 (HPE5). It belongs to the zinc finger protein of the cerebellum (Zic) family of genes that share a C2H2-type zinc finger domain, similar to the GLI family of genes. In order to clarify the role of Zic2 in gene regulation, we searched for it...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ishiguro, Akira, Hatayama, Minoru, Otsuka, Maky I., Aruga, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794963/
https://ncbi.nlm.nih.gov/pubmed/29391420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20242-2
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