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Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome

The N-terminal domains of the herpesvirus large tegument proteins encode a conserved cysteine protease with ubiquitin- and NEDD8-specific deconjugase activity. The proteins are expressed during the productive virus cycle and are incorporated into infectious virus particles, being delivered to the ta...

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Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Gupta, Soham, Ylä-Anttila, Päivi, Callegari, Simone, Tsai, Ming-Han, Delecluse, Henri-Jacques, Masucci, Maria G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794190/
https://ncbi.nlm.nih.gov/pubmed/29357390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006852
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