Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome

The N-terminal domains of the herpesvirus large tegument proteins encode a conserved cysteine protease with ubiquitin- and NEDD8-specific deconjugase activity. The proteins are expressed during the productive virus cycle and are incorporated into infectious virus particles, being delivered to the ta...

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Publicado en:PLoS Pathog
Autores principales: Gupta, Soham, Ylä-Anttila, Päivi, Callegari, Simone, Tsai, Ming-Han, Delecluse, Henri-Jacques, Masucci, Maria G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794190/
https://ncbi.nlm.nih.gov/pubmed/29357390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006852
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