Mapping protein interactions of sodium channel Na(V)1.7 using epitope‐tagged gene‐targeted mice

The voltage‐gated sodium channel Na(V)1.7 plays a critical role in pain pathways. We generated an epitope‐tagged Na(V)1.7 mouse that showed normal pain behaviours to identify channel‐interacting proteins. Analysis of Na(V)1.7 complexes affinity‐purified under native conditions by mass spectrometry r...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Kanellopoulos, Alexandros H, Koenig, Jennifer, Huang, Honglei, Pyrski, Martina, Millet, Queensta, Lolignier, Stéphane, Morohashi, Toru, Gossage, Samuel J, Jay, Maude, Linley, John E, Baskozos, Georgios, Kessler, Benedikt M, Cox, James J, Dolphin, Annette C, Zufall, Frank, Wood, John N, Zhao, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793798/
https://ncbi.nlm.nih.gov/pubmed/29335280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201796692
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