Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Na(v)1.7

Loss-of-function mutations in the SCN9A gene encoding voltage-gated sodium channel Na(v)1.7 cause congenital insensitivity to pain in humans and mice. Surprisingly, many potent selective antagonists of Na(v)1.7 are weak analgesics. We investigated whether Na(v)1.7, as well as contributing to electri...

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Pubblicato in:Nat Commun
Autori principali: Minett, Michael S., Pereira, Vanessa, Sikandar, Shafaq, Matsuyama, Ayako, Lolignier, Stéphane, Kanellopoulos, Alexandros H., Mancini, Flavia, Iannetti, Gian D., Bogdanov, Yury D., Santana-Varela, Sonia, Millet, Queensta, Baskozos, Giorgios, MacAllister, Raymond, Cox, James J., Zhao, Jing, Wood, John N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686868/
https://ncbi.nlm.nih.gov/pubmed/26634308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9967
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