A central mechanism of analgesia in mice and humans lacking the sodium channel Na(V)1.7

Deletion of SCN9A encoding the voltage-gated sodium channel Na(V)1.7 in humans leads to profound pain insensitivity and anosmia. Conditional deletion of Na(V)1.7 in sensory neurons of mice also abolishes pain, suggesting that the locus of analgesia is the nociceptor. Here we demonstrate, using in vi...

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Publicado en:Neuron
Main Authors: MacDonald, Donald Iain, Sikandar, Shafaq, Weiss, Jan, Pyrski, Martina, Luiz, Ana P., Millet, Queensta, Emery, Edward C., Mancini, Flavia, Iannetti, Gian D., Alles, Sascha R.A., Arcangeletti, Manuel, Zhao, Jing, Cox, James J., Brownstone, Robert M., Zufall, Frank, Wood, John N.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110947/
https://ncbi.nlm.nih.gov/pubmed/33823138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2021.03.012
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