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Prion-Like Characteristics of Polyglutamine-Containing Proteins

Transmissible spongiform encephalopathies are infectious neurodegenerative diseases caused by the conversion of prion protein (PrP) into a self-replicating conformation that spreads via templated conversion of natively folded PrP molecules within or between cells. Recent studies provide compelling e...

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Pubblicato in:Cold Spring Harb Perspect Med
Autori principali: Pearce, Margaret M.P., Kopito, Ron R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793740/
https://ncbi.nlm.nih.gov/pubmed/28096245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a024257
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