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MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib
As a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), osimeritnib is the standard treatment for patients with non-small cell lung cancer harboring the EGFR T790M mutation; however, acquired resistance inevitably develops. Therefore, a next-generation treatmen...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5792548/ https://ncbi.nlm.nih.gov/pubmed/29386539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20326-z |
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