MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib

As a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), osimeritnib is the standard treatment for patients with non-small cell lung cancer harboring the EGFR T790M mutation; however, acquired resistance inevitably develops. Therefore, a next-generation treatmen...

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Vydáno v:Sci Rep
Hlavní autoři: Ninomiya, Kiichiro, Ohashi, Kadoaki, Makimoto, Go, Tomida, Shuta, Higo, Hisao, Kayatani, Hiroe, Ninomiya, Takashi, Kubo, Toshio, Ichihara, Eiki, Hotta, Katsuyuki, Tabata, Masahiro, Maeda, Yoshinobu, Kiura, Katsuyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792548/
https://ncbi.nlm.nih.gov/pubmed/29386539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20326-z
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