PRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex Assembly

Mutations in proline-rich transmembrane protein 2 (PRRT2) are associated with a range of paroxysmal neurological disorders. PRRT2 predominantly localizes to the pre-synaptic terminals and is believed to regulate neurotransmitter release. However, the mechanism of action is unclear. Here, we use reco...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Coleman, Jeff, Jouannot, Ouardane, Ramakrishnan, Sathish K., Zanetti, Maria N., Wang, Jing, Salpietro, Vincenzo, Houlden, Henry, Rothman, James E., Krishnakumar, Shyam S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792450/
https://ncbi.nlm.nih.gov/pubmed/29346777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.12.056
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