Tau Reduction Prevents Neuronal Loss and Reverses Pathological Tau Deposition and Seeding in Mice with Tauopathy

Accumulation of hyperphosphorylated tau directly correlates with cognitive decline in Alzheimer’s disease and other primary tauopathies. One therapeutic strategy may be to reduce total tau expression. We identified antisense oligonucleotides (ASOs) that selectively decreased human tau mRNA and prote...

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發表在:Sci Transl Med
Main Authors: DeVos, Sarah L., Miller, Rebecca L., Schoch, Kathleen M., Holmes, Brandon B., Kebodeaux, Carey S., Wegener, Amy J., Chen, Guo, Shen, Tao, Tran, Hien, Nichols, Brandon, Zanardi, Tom A., Kordasiewicz, Holly B., Swayze, Eric E., Bennett, C. Frank, Diamond, Marc I., Miller, Timothy M.
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792300/
https://ncbi.nlm.nih.gov/pubmed/28123067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag0481
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