Tau Reduction Prevents Neuronal Loss and Reverses Pathological Tau Deposition and Seeding in Mice with Tauopathy

Accumulation of hyperphosphorylated tau directly correlates with cognitive decline in Alzheimer’s disease and other primary tauopathies. One therapeutic strategy may be to reduce total tau expression. We identified antisense oligonucleotides (ASOs) that selectively decreased human tau mRNA and prote...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: DeVos, Sarah L., Miller, Rebecca L., Schoch, Kathleen M., Holmes, Brandon B., Kebodeaux, Carey S., Wegener, Amy J., Chen, Guo, Shen, Tao, Tran, Hien, Nichols, Brandon, Zanardi, Tom A., Kordasiewicz, Holly B., Swayze, Eric E., Bennett, C. Frank, Diamond, Marc I., Miller, Timothy M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792300/
https://ncbi.nlm.nih.gov/pubmed/28123067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag0481
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