Muscle paralysis induces bone marrow inflammation and predisposition to formation of giant osteoclasts

Transient muscle paralysis engendered by a single injection of botulinum toxin A (BTxA) rapidly induces profound focal bone resorption within the medullary cavity of adjacent bones. While initially conceived as a model of mechanical disuse, osteoclastic resorption in this model is disproportionately...

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Vydáno v:Am J Physiol Cell Physiol
Hlavní autoři: Ausk, Brandon J., Worton, Leah E., Smigiel, Kate S., Kwon, Ronald Y., Bain, Steven D., Srinivasan, Sundar, Gardiner, Edith M., Gross, Ted S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792168/
https://ncbi.nlm.nih.gov/pubmed/28855162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00363.2016
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