Distinct Cyclosporin A Doses Are Required to Enhance Bone Formation Induced by Cyclic and Rest-Inserted Loading in the Senescent Skeleton

Age-related decline in periosteal adaptation negatively impacts the ability to utilize exercise to enhance bone mass and strength in the elderly. We recently observed that in senescent animals subject to cyclically applied loading, supplementation with Cyclosporin A (CsA) substantially enhanced the...

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Autori principali: Srinivasan, Sundar, Threet, Dewayne, Worton, Leah E., Ausk, Brandon J., Bain, Steven D., Gardiner, Edith M., Kwon, Ronald Y., Gross, Ted S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880323/
https://ncbi.nlm.nih.gov/pubmed/24404194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084868
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