ABCC6 plays a significant role in the transport of nilotinib and dasatinib, and contributes to TKI resistance in vitro, in both cell lines and primary patient mononuclear cells

ATP Binding Cassette family efflux proteins ABCB1 and ABCG2 have previously been demonstrated to interact with Tyrosine Kinase Inhibitors (TKIs); however, evidence for the interaction of other potentially relevant drug transporters with TKIs is lacking. Through Taqman transporter array technology we...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Eadie, Laura N., Dang, Phuong, Goyne, Jarrad M., Hughes, Timothy P., White, Deborah L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792028/
https://ncbi.nlm.nih.gov/pubmed/29385210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192180
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