Activation of PI3K, Akt, and ERK during early rotavirus infection leads to V-ATPase-dependent endosomal acidification required for uncoating

The cellular PI3K/Akt and/or MEK/ERK signaling pathways mediate the entry process or endosomal acidification during infection of many viruses. However, their roles in the early infection events of group A rotaviruses (RVAs) have remained elusive. Here, we show that late-penetration (L-P) human DS-1...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Soliman, Mahmoud, Seo, Ja-Young, Kim, Deok-Song, Kim, Ji-Yun, Park, Jun-Gyu, Alfajaro, Mia Madel, Baek, Yeong-Bin, Cho, Eun-Hyo, Kwon, Joseph, Choi, Jong-Soon, Kang, Mun-Il, Park, Sang-Ik, Cho, Kyoung-Oh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792019/
https://ncbi.nlm.nih.gov/pubmed/29352319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006820
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