Rotavirus-Induced Early Activation of the RhoA/ROCK/MLC Signaling Pathway Mediates the Disruption of Tight Junctions in Polarized MDCK Cells

Intestinal epithelial tight junctions (TJ) are a major barrier restricting the entry of various harmful factors including pathogens; however, they also represent an important entry portal for pathogens. Although the rotavirus-induced early disruption of TJ integrity and targeting of TJ proteins as c...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Soliman, Mahmoud, Cho, Eun-Hyo, Park, Jun-Gyu, Kim, Ji-Yun, Alfajaro, Mia Madel, Baek, Yeong-Bin, Kim, Deok-Song, Kang, Mun-Il, Park, Sang-Ik, Cho, Kyoung-Oh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141481/
https://ncbi.nlm.nih.gov/pubmed/30224682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32352-y
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