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The potential of CRL4DCAF1 and KSR1 as therapeutic targets in merlin-deficient meningioma

BACKGROUND: Merlin-deficient meningiomas are caused by mutations in the Neurofibromin 2 gene and occur in approximately 60% of sporadic meningiomas. Merlin loss is commonly associated with the genetic condition Neurofibromatosis type 2, leading to the development of multiple low grade tumours includ...

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Publicat a:Neuro Oncol
Autors principals: Rimmer, Jade Lyons, Baiz, Daniele, Ercolano, Emanuela, Hanemann, Oliver
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791592/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox238.041
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