Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells

Combination of drugs that target different aspects of aberrant cellular processes is an efficacious treatment for hematological malignancies. Hypomethylating agents (HMAs) and inhibitors of poly(ADP-ribose) polymerases (PARPis) and histone deacetylases (HDACis) are clinically active anti-tumor drugs...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Valdez, Benigno C., Li, Yang, Murray, David, Liu, Yan, Nieto, Yago, Champlin, Richard E., Andersson, Borje S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790510/
https://ncbi.nlm.nih.gov/pubmed/29423093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23386
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