Genomic landscape of advanced basal cell carcinoma: Implications for precision treatment with targeted and immune therapies

Metastatic basal cell cancer (BCC) is an ultra-rare malignancy with no approved therapies beyond Hedgehog inhibitors. We characterized the genomics, tumor mutational burden (TMB), and anti-PD-1 therapy responses in patients with locally advanced or metastatic BCC. Overall, 2,039 diverse cancer sampl...

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Vydáno v:Oncoimmunology
Hlavní autoři: Goodman, Aaron M., Kato, Shumei, Cohen, Philip R., Boichard, Amélie, Frampton, Garrett, Miller, Vincent, Stephens, Philip J., Daniels, Gregory A., Kurzrock, Razelle
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2017
Témata:
Brief Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790366/
https://ncbi.nlm.nih.gov/pubmed/29399405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1404217
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