Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapy

Metastatic basal cell carcinomas are rare malignancies harbouring Hedgehog pathway alterations targetable by SMO antagonists (vismodegib/sonidegib). We describe, for the first time, the molecular genetics and response of a patient with Hedgehog inhibitor-resistant metastatic basal cell carcinoma who...

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Bibliografski detalji
Izdano u:NPJ Genom Med
Glavni autori: Ikeda, Sadakatsu, Goodman, Aaron M, Cohen, Philip R, Jensen, Taylor J, Ellison, Christopher K, Frampton, Garrett, Miller, Vincent, Patel, Sandip P, Kurzrock, Razelle
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Case Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142752/
https://ncbi.nlm.nih.gov/pubmed/27942391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjgenmed.2016.37
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