Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy

BACKGROUND. Reversing immune exhaustion with an anti-PD-L1 antibody may improve human immunodeficiency virus type 1 (HIV-1)–specific immunity and increase clearance of HIV-1–expressing cells. METHODS. We conducted a phase I, randomized, double-blind, placebo-controlled, dose-escalating study of BMS-...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Gay, Cynthia L., Bosch, Ronald J, Ritz, Justin, Hataye, Jason M., Aga, Evgenia, Tressler, Randall L., Mason, Stephen W., Hwang, Carey K., Grasela, Dennis M., Ray, Neelanjana, Cyktor, Josh C., Coffin, John M., Acosta, Edward P., Koup, Richard A., Mellors, John W., Eron, Joseph J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Major Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790148/
https://ncbi.nlm.nih.gov/pubmed/28431010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix191
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