IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways

Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two distinct and predominant types of human lung cancer. IκB kinase α (IKKα) has been shown to suppress lung SCC development, but its role in ADC is unknown. We found inactivating mutations and homologous or hemizygous deletions in the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Song, Na-Young, Zhu, Feng, Wang, Zining, Willette-Brown, Jami, Xi, Sichuan, Sun, Zhonghe, Su, Ling, Wu, Xiaolin, Ma, Buyong, Nussinov, Ruth, Xia, Xiaojun, Schrump, David S., Johnson, Peter F., Karin, Michael, Hu, Yinling
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789942/
https://ncbi.nlm.nih.gov/pubmed/29311298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717520115
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